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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: FOXO1 All Species: 19.09
Human Site: T412 Identified Species: 42
UniProt: Q12778 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.1
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q12778 NP_002006.2 655 69662 T412 Y S F A P P N T S L N S P S P
Chimpanzee Pan troglodytes XP_522749 829 87557 T586 Y S F A P P N T S L N S P S P
Rhesus Macaque Macaca mulatta XP_001088437 860 91177 T617 Y S F A P P N T S L N S P S P
Dog Lupus familis XP_534487 524 56894 L283 F A P P N T S L N S P S P N Y
Cat Felis silvestris
Mouse Mus musculus Q9R1E0 652 69484 T409 Y S F A P P N T S L N S P S P
Rat Rattus norvegicus XP_342245 649 69326 T406 Y S F A P P N T S L N S P S P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512968 514 54918 P273 A P G Y S F A P P N A S M S S
Chicken Gallus gallus Q90964 451 48838 D210 K V P R H Y D D P G K G N Y W
Frog Xenopus laevis Q6EUW2 631 68449 Q386 S P A S M M Q Q S G Y L F T S
Zebra Danio Brachydanio rerio NP_001070725 652 69329 T405 L S A V S Q Q T Q Q D F R K C
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q95V55 613 67394 L372 Q P Q S Q C L L H R S L N C S
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 79 75.4 74.8 N.A. 92.6 92.2 N.A. 63.3 21.9 66.4 59.3 N.A. 29.7 N.A. N.A. N.A.
Protein Similarity: 100 79 75.6 77.2 N.A. 95.5 95.2 N.A. 69.9 35.4 76.7 72 N.A. 41.9 N.A. N.A. N.A.
P-Site Identity: 100 100 100 13.3 N.A. 100 100 N.A. 13.3 0 6.6 13.3 N.A. 0 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 46.6 N.A. 100 100 N.A. 13.3 6.6 20 20 N.A. 13.3 N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 10 10 19 46 0 0 10 0 0 0 10 0 0 0 0 % A
% Cys: 0 0 0 0 0 10 0 0 0 0 0 0 0 10 10 % C
% Asp: 0 0 0 0 0 0 10 10 0 0 10 0 0 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 10 0 46 0 0 10 0 0 0 0 0 10 10 0 0 % F
% Gly: 0 0 10 0 0 0 0 0 0 19 0 10 0 0 0 % G
% His: 0 0 0 0 10 0 0 0 10 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 10 0 0 0 0 0 0 0 0 0 10 0 0 10 0 % K
% Leu: 10 0 0 0 0 0 10 19 0 46 0 19 0 0 0 % L
% Met: 0 0 0 0 10 10 0 0 0 0 0 0 10 0 0 % M
% Asn: 0 0 0 0 10 0 46 0 10 10 46 0 19 10 0 % N
% Pro: 0 28 19 10 46 46 0 10 19 0 10 0 55 0 46 % P
% Gln: 10 0 10 0 10 10 19 10 10 10 0 0 0 0 0 % Q
% Arg: 0 0 0 10 0 0 0 0 0 10 0 0 10 0 0 % R
% Ser: 10 55 0 19 19 0 10 0 55 10 10 64 0 55 28 % S
% Thr: 0 0 0 0 0 10 0 55 0 0 0 0 0 10 0 % T
% Val: 0 10 0 10 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % W
% Tyr: 46 0 0 10 0 10 0 0 0 0 10 0 0 10 10 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _